G-6-PDH

Glucose-6-phosphate dehydrogenase (G-6-PDH) deficiency is the red cell enzymopathy in humans and has an X-linked inheritance. It has been reported from India more than 30 years ago and the prevalence varies from 0-27% in different caste, ethnic and linguistic groups. The major clinical manifestations are drug induced hemolytic anemia, neonatal jaundice and chronic non-spherocytic hemolytic anemia.

Individuals with G-6-PDH deficiency have a selective advantage against Plasmodium falciparum which causes malaria. Thirteen biochemically characterized variants have been reported from India. At the molecular level, G-6-PDH Mediterranean is the most common deficient variant in the caste groups whereas, G-6-PDH Orissa is more prevalent among the tribal of India. The third common variant seen in India is G-6-PDH Kerala-Kalyan.*(1)

G-6-PDH deficiency is a common cause of persistent jaundice in newborns. If left untreated, this can lead to significant brain damage and mental retardation. (1)

With hemolytic anemia, RBCs are destroyed at an accelerated rate and the person affected becomes pale and fatigued (anemic) as their capacity for providing oxygen to their body decreases. In severe cases of RBC destruction, jaundice can also be present. Most of these episodes are self-limiting, but if a large number of RBCs are destroyed and the body cannot replace them fast enough, then the affected person may require a blood transfusion. This condition can be fatal if not treated. A small percentage of those affected with G-6-PDH deficiency may experience chronic anemia. (2)

DiaSys G-6-PDH

DiaSys known for its clinical chemistry range of products has added a new dimension in its portfolio. The launch of G-6-PDH adds peadritric diagnostic solution, which helps speciality labs support their patients which quality reports.

Key features:

• Superior Methodology
• Excellent clinical correlation
• User Friendly
• Liquid Stable ready to use reagent
• Freedom from interferences
• Measuring range 5 to 3000 U/L
• High on board stability
• Applicable on various clinical chemistry analyers.

1 - Glucose-6-phosphate dehydrogenase deficiency in India Dipika Mohanty 1, Malay B Mukherjee, Roshan B Colah
2 - www.testing.com/tests/g6pd/